In Assassin's Creed Revelations, Ezio Auditore visits Constantinople while searching for Altaïr's Masyaf keys.
The game is set primarily in Constantinople, the capital of the Byzantine Empire, during the early sixteenth century. Ezio arrives there to locate five keys linked to Masyaf and Altaïr's legacy. The city is divided into districts and includes a storyline involving Ottoman political factions, the Byzantine remnants, and the local Assassin leadership.
Constantinople was renamed Istanbul in official usage by the Turkish Republic in the twentieth century, but the historical setting of Revelations uses the older name. Ezio's search connects his story to Altaïr, whose memories appear in separate sequences. This cross-generational structure is a defining feature of Revelations rather than a new version of the Animus premise.