In Assassin's Creed Revelations, which historic city is the game's main setting?

In Assassin's Creed Revelations, Constantinople is the game's main setting.

The game follows an older Ezio Auditore as he travels to Constantinople, the capital of the Byzantine Empire, in search of keys connected to Altaïr Ibn-La'Ahad's legacy. The city is divided into districts and offers a dense urban environment for missions, exploration, and Assassin recruitment.

Constantinople was a major center linking Europe and Asia. In the historical period represented by the game, it was under Ottoman rule and had been renamed Istanbul in official usage by the modern era. The game uses the historical name Constantinople for its sixteenth-century setting.

Revelations also includes sequences set in Masyaf and a series of memories involving Altaïr. Jerusalem and Damascus are central locations in the first Assassin's Creed, while Alexandria is prominent in Origins. These overlapping locations can cause confusion between games.