Bayek of Siwa is the protagonist of Assassin's Creed Origins, which is set in ancient Egypt.
Bayek is a Medjay, a protector and law officer from the Siwa Oasis. After a personal tragedy, he pursues members of a hidden organization whose actions threaten Egypt. His investigation gradually connects to the origins of the Hidden Ones, the group that later develops into the Assassin Brotherhood.
Aya, Bayek's wife, is also a major playable character and an important founder of the Hidden Ones. That makes her a frequent alternative answer, but the game's principal protagonist is Bayek. Senu is Bayek's eagle companion, not a human character.
Origins was released in 2017 and takes place during the final period of the Ptolemaic Kingdom. Its setting includes Alexandria, Memphis, Cyrene, and the Great Sphinx, while its redesigned combat and role-playing systems marked a significant change for the series.