In Assassin's Creed Origins, Bayek's wife is Aya, who becomes an important Hidden One.
Aya is a Greek-Egyptian woman from Alexandria and a skilled agent whose political connections and personal convictions shape the game's story. She and Bayek begin the game as Medjay partners and spouses, but the murder of their son, Khemu, drives them into a campaign against the masked members of the Order of the Ancients.
Aya is not merely a supporting character. She takes part in major missions, works with Cleopatra, and helps turn Bayek's pursuit of revenge into a broader struggle against abuses of power. Near the end of the story, she adopts the Roman name Amunet and becomes central to the formation of the Hidden Ones, the organization that later develops into the Assassin Brotherhood.
Khemu is Bayek and Aya's son, not Aya's name. Senu is Bayek's eagle companion, while Cleopatra is the historical queen with whom Aya and Bayek become involved. Those names all appear prominently in the game but refer to different characters.