In Assassin's Creed III, Boston is the setting for the game's opening sequence. The early chapters follow Haytham Kenway and later Connor through the colonial city before the story expands across the American Revolution.
The game opens in 1754, during the French and Indian War, and introduces Haytham before shifting the player's focus to his son, Ratonhnhaké:ton, commonly known as Connor. Boston becomes one of the principal urban environments in which Connor investigates Templar activity, meets historical figures, and becomes involved in revolutionary events.
New York is also a major playable city in Assassin's Creed III, which makes it an easy alternative. Philadelphia and Charleston are important places in the wider history of the American Revolution but are not the answer to this opening-sequence question. The game's Frontier region connects Boston and New York and provides a separate environment for hunting, travel, and story missions.