Venice is the Italian city featured in Assassin's Creed II with the Palazzo Ducale and the Rialto Bridge.
The game places Ezio Auditore's Renaissance adventures across several Italian locations, including Florence, Monteriggioni, Forlì, and Venice. Venice becomes especially important during the later part of the main story, when Ezio investigates conspiracies connected to the city's powerful families and institutions.
The Palazzo Ducale, or Doge's Palace, and the Rialto Bridge are real Venetian landmarks represented in the game world. Their inclusion helps give the setting a recognizable historical identity, although the game compresses geography and alters some buildings for gameplay.
Venice is often confused with Florence in questions about Assassin's Creed II because Florence is Ezio's birthplace and an important early setting. They are distinct cities with different roles in the story.