Venice is the Italian city featured in Assassin's Creed II missions involving the Palazzo Ducale.
Assassin's Creed II moves Ezio Auditore's story through several Renaissance locations, including Florence, Monteriggioni, Tuscany, Forlì, and Venice. Venice becomes especially important in the latter part of the campaign, where its canals, rooftops, churches, and palaces provide the setting for major missions.
The Palazzo Ducale, also known as the Doge's Palace, is a real Gothic palace beside St Mark's Basilica. In the game, its recognizable architecture is adapted for climbing, infiltration, and pursuit. The historical building was the residence of the doge and a center of government in the Republic of Venice.
Florence is another major city in Assassin's Creed II and the location most associated with the early chapters of Ezio's journey. That is why the two cities are commonly mixed up. Venice is the answer for the Palazzo Ducale setting, while Florence contains landmarks such as Santa Maria del Fiore and the Palazzo della Signoria.