In Assassin's Creed II, which historical figure is the main Templar antagonist Rodrigo Borgia?

In Assassin's Creed II, the main Templar antagonist Rodrigo Borgia is depicted as Pope Alexander VI.

Rodrigo Borgia was a real Spanish-born cleric who became pope in 1492, taking the papal name Alexander VI. The game uses this historical identity in its late-story confrontation with Ezio Auditore, while adapting events and relationships for its fictional Assassin-Templar narrative.

The character is shown as the leader of the Italian Templars and a powerful political operator. His historical papacy is associated with the Borgia family, whose members also appear throughout the game and its follow-up, Assassin's Creed Brotherhood.

This fact is often confused with other Renaissance figures in the game. Lorenzo de' Medici is a Florentine ruler and ally, Machiavelli is an Assassin adviser, and Julius II became pope later, in 1503.