In Assassin's Creed II, Ezio Auditore's uncle who runs the Villa Auditore refuge is Mario Auditore.
Mario is introduced as the lord of Monteriggioni and the guardian of Villa Auditore, a fortified estate in Tuscany. After Ezio's family is destroyed, Mario helps him escape Florence, explains the family's connection to the Assassins, and begins training him in combat and Assassin methods.
The villa later becomes a strategic base that players can improve by restoring buildings, shops, and services. Its development provides income and unlocks practical benefits during Ezio's campaign.
The Auditore family names can be easy to confuse. Giovanni is Ezio's father, Federico is his older brother, and Petruccio is his younger brother. Mario is the uncle and established Assassin who supports Ezio after the tragedy.