In Assassin's Creed Brotherhood, which Roman landmark serves as Ezio's main base?

In Assassin's Creed Brotherhood, Ezio's main Roman base is the Isola Tiberina.

The Isola Tiberina is a real island in the Tiber River and serves as the headquarters of the rebuilt Roman Assassin Brotherhood in the game. Ezio uses it to meet allies, manage recruits, and coordinate operations against the Borgia regime. Its location gives the Brotherhood a hidden but strategically useful base inside Rome.

Castel Sant'Angelo, the Colosseum, and the Pantheon are all major Roman landmarks featured in Brotherhood, which makes them plausible alternatives. Castel Sant'Angelo is especially important to the Borgia storyline, but it is not Ezio's headquarters. The Isola Tiberina is the specific island base.

Brotherhood was released in 2010 and continues Ezio's story after Assassin's Creed II. It introduces a stronger recruit-and-command system, letting Ezio train Assassins and call them into missions. The game is set primarily in Rome during the early sixteenth century and focuses on dismantling Cesare Borgia's power.