In Assassin's Creed: Brotherhood, which Roman landmark serves as Ezio's headquarters?

In Assassin's Creed: Brotherhood, the Tiber Island Hideout serves as Ezio's headquarters. The hideout is located on Rome's Tiber Island and becomes the operational center for the rebuilt Roman Assassin Brotherhood.

Ezio reaches Rome after the destruction of Monteriggioni and the Villa Auditore in the game's opening sequence. From the island, he recruits Assassins, receives missions, manages equipment, and coordinates resistance against the Borgia family.

The hideout is associated with the real Basilica of San Bartolomeo all'Isola, although the game adapts the location for its fictional narrative. Rome itself functions as the principal open-world setting of Brotherhood.

Villa Auditore remains important as Ezio's earlier base in Monteriggioni, especially in Assassin's Creed II. It is not the headquarters used for the main Roman campaign in Brotherhood.