In Assassin's Creed Brotherhood, which historical pope leads the Borgia family?

In Assassin's Creed Brotherhood, Pope Alexander VI leads the Borgia family.

Pope Alexander VI is the papal name of Rodrigo Borgia, who serves as the principal Templar antagonist in the game. His son Cesare Borgia commands the Borgia military forces and becomes Ezio Auditore's central enemy. Their power base is Rome, where the game's campaign is largely set.

The historical Rodrigo Borgia was elected pope in 1492 and held the office until his death in 1503. Brotherhood fictionalizes his connection to the Templars and the Apple of Eden, but it places real political figures and locations into a dramatized Renaissance narrative.

Julius II, Innocent VIII, and Leo X were also real Renaissance popes, yet they are different historical figures. Brotherhood was released in 2010 and continues Ezio's story after Assassin's Creed II, focusing on rebuilding the Assassin Brotherhood and freeing Rome from Borgia control.