Cesare Borgia leads the Borgia forces against Ezio in Assassin’s Creed Brotherhood.
Cesare is the principal human antagonist of Brotherhood. He commands military forces while his father, Rodrigo Borgia, serves as the elected pope Alexander VI. The game presents Cesare as an ambitious and violent power seeker whose campaign threatens Rome and the surrounding territories.
Ezio’s objective is not simply to defeat Cesare in a single battle. He works to dismantle Borgia control across Rome by liberating districts, recruiting assassins, destroying military assets, and recovering influence for the Assassin Brotherhood. This structure makes Cesare’s military role central to the game’s plot and gameplay.
Rodrigo Borgia was the primary antagonist of Assassin’s Creed II and remains important in Brotherhood, but he is not the commander asked for here. Cesare and Rodrigo were real historical figures from the Borgia family, though the game dramatizes their relationships and activities as part of its fictional narrative.