Rome is Ezio's main base in Assassin's Creed Brotherhood.
Brotherhood places Ezio in Renaissance Rome, where the Borgia family controls much of the city. Ezio works to weaken their influence, rebuild the local Assassin Brotherhood, and recruit allies. The city is divided into districts whose shops, landmarks, and facilities can be restored as the player progresses.
The game includes the Vatican and the surrounding Roman countryside, but Rome remains its central setting. Florence and Venice are strongly associated with Ezio because they are important locations in Assassin's Creed II. Naples appears in the broader Italian historical world, but it is not Brotherhood's main base. The game also introduces a larger emphasis on recruiting and directing fellow Assassins.