Rome is the historic city that Ezio Auditore makes the base of the Assassins in Assassin's Creed Brotherhood.
The game is set primarily in Rome during the early sixteenth century. The city is dominated by the Borgia family, whose political and military power has weakened the local Assassin network.
Ezio works to rebuild that network by liberating districts, recruiting new members, and striking at Borgia influence. He also manages the renovation of shops and landmarks, turning the damaged city into a stronger economic and operational base.
Brotherhood continues Ezio's story after Assassin's Creed II, but it is not mainly set in Florence or Venice. Those cities are important to the earlier game, whereas Rome is the central location for Brotherhood's campaign and its expanded Brotherhood-management systems.