The Borgias lead the main Templar opposition in Assassin’s Creed: Brotherhood. The game portrays the powerful Borgia family as the dominant force controlling Rome and opposing Ezio Auditore’s Brotherhood.
Rodrigo Borgia, known in the game as Pope Alexander VI, serves as a major antagonist, while his son Cesare Borgia commands military and political power. Their influence gives Ezio a broad campaign target rather than a single isolated enemy.
The historical Borgias were a prominent Renaissance family with Spanish origins. Assassin’s Creed: Brotherhood fictionalizes their role within the series’ long-running secret conflict, combining documented figures and locations with invented conspiracies.
Ezio’s campaign involves attacking Borgia strongholds, dismantling their influence, and restoring Roman districts. This structure also supports the game’s Brotherhood-building mechanics, because liberated areas provide opportunities to recruit and train new Assassins.