In Assassin’s Creed Brotherhood, Ezio helps liberate Rome from Borgia control.
The game is set mainly in Rome in 1500 and 1507, where Cesare Borgia and his allies dominate the city through military force, political influence, and economic control. Ezio works with the Roman Brotherhood to weaken that system by reclaiming districts, recruiting Assassins, and dismantling Borgia operations.
Rome’s landmarks are central to the story. The Colosseum, Castel Sant’Angelo, the Pantheon, and the Vatican area all appear as locations connected to missions and exploration. The city is larger and more continuous than the multi-city structure used in Assassin’s Creed II.
Ezio’s campaign also expands the role of the Assassin Brotherhood. Rather than operating alone, he trains recruits and coordinates a network. That emphasis on rebuilding an organized brotherhood gives the game its title and distinguishes it from Ezio’s earlier adventure.