Rome is the city Ezio Auditore works to liberate from the Borgia in Assassin's Creed: Brotherhood.
The game is set primarily in Rome during the early sixteenth century, when the Borgia family controls much of the city's political and military power. Ezio confronts Cesare Borgia and his allies while rebuilding the weakened Assassin Brotherhood.
Unlike Assassin's Creed II, which moves between several Italian cities, Brotherhood concentrates most of its historical campaign in one large urban environment. Ezio recruits new Assassins, restores shops and landmarks, and weakens Borgia influence across Rome's districts.
The game's title reflects its emphasis on organizing a larger Brotherhood rather than working alone. Rome's landmarks, including the Colosseum, the Pantheon, and Castel Sant'Angelo, are woven into missions and exploration. The Borgia campaign also continues the conflict introduced near the end of Assassin's Creed II.