In Assassin’s Creed Brotherhood, which Borgia family member is the main antagonist?

Cesare Borgia is the main antagonist of Assassin’s Creed Brotherhood.

Cesare is a powerful military commander and the son of Rodrigo Borgia, who appeared as the principal antagonist of Assassin’s Creed II. In Brotherhood, Cesare seeks to expand Borgia control across Italy and becomes Ezio Auditore’s central enemy.

The story is set largely in Rome, where Ezio rebuilds the Assassin Brotherhood, recruits allies and attacks Borgia influence. Cesare’s historical ambitions are adapted into the game’s fictionalized conflict between Templars and Assassins.

Rodrigo remains important, but he is not Brotherhood’s main antagonist. Lucrezia Borgia appears as Cesare’s sister, and Juan Borgia is another member of the family. Their shared surname and historical prominence make them easy to confuse.