In Assassin's Creed Brotherhood, Cesare Borgia is Ezio Auditore's main enemy and the campaign's principal Borgia leader. Cesare commands military forces and seeks to expand Borgia power across Italy.
The game follows Ezio in Rome, where he rebuilds the Assassin Brotherhood and works to weaken Cesare's control of the city. Cesare is the son of Rodrigo Borgia, who appears as Pope Alexander VI and serves as an important antagonist in Assassin's Creed II. Brotherhood shifts the central conflict toward Cesare's ambitions and military campaign.
Rodrigo is therefore a common mix-up, but he is Cesare's father rather than the primary enemy in this installment. Juan Borgia is Cesare's brother, while Micheletto Corella is an associate and enforcer. The historical Cesare Borgia also inspired the game's characterization, though the plot uses substantial fictionalization.