How many issues are in the main The Boys comic series? The main series contains 72 issues.
The numbered run began in 2006 and ended in November 2012 with issue #72. The first six issues were released by WildStorm, then Dynamite Entertainment took over from issue #7 after the title’s move away from DC Comics’ imprint.
The number 72 applies specifically to the main series, which is what makes it the canonical answer to this quiz question. The franchise also includes separate limited series and an epilogue, so counting every comic publication produces a larger total. Those related projects include Herogasm, Highland Laddie, Butcher, Baker, Candlestickmaker, and Dear Becky.
The collected editions can make the numbering confusing because they group several individual issues into trade paperbacks, hardcover volumes, or omnibus editions. Those books are formats for collecting the material, not additional main-series issues. Thus, whether readers encounter the story in single issues or collections, the original core run stops at issue #72.