Against which team did Babe Ruth hit his 500th career home run?

Babe Ruth hit his 500th career home run against the Cleveland Indians. He reached the milestone on August 11, 1929, at League Park in Cleveland, becoming the first player in major-league history to hit 500 home runs.

Ruth's milestone blast came in the second inning against Indians pitcher Willis Hudlin. It was a solo home run that traveled over the right-field fence and became one of the defining moments of his already historic career. At the time, no other player had approached Ruth's combination of power and consistency on such a scale.

The achievement was especially significant because Ruth had revolutionized offensive baseball during the 1920s. He had already set the single-season home-run record several times, including his famous 60-homer season in 1927. Ruth eventually finished with 714 career home runs, a record that stood until Hank Aaron surpassed it in 1974. The team name “Cleveland Indians” is historically correct for 1929; the franchise adopted the Guardians name in 2021.