Which singer opened the 2025 American Music Awards with "Dance Again"?

Jennifer Lopez opened the 2025 American Music Awards with “Dance Again.”

The May 26, 2025 ceremony began with Lopez performing a short rendition of her 2012 song before expanding into an energetic medley of 23 songs associated with major recent hits. The six-minute number showcased her singing, dancing, and elaborate staging before she continued as the evening’s host.

“Dance Again” was released as a single from Lopez’s seventh studio album, Love?, and features rapper Pitbull. Its appearance at the AMAs connected the opening to Lopez’s own catalog rather than making the performance solely a medley of other artists’ songs.

The 2025 AMAs were the 51st ceremony and took place at Fontainebleau Las Vegas, marking the show’s move away from its familiar Los Angeles setting. Janet Jackson also performed and received the Icon Award, which is why viewers may remember her as one of the night’s major figures without being the opening singer.