Which Renaissance Assassin is the main protagonist of Assassin's Creed II?

Ezio Auditore is the main protagonist of Assassin's Creed II.

Ezio is a Florentine nobleman whose life changes after members of his family are executed. He begins a personal campaign for answers and revenge, then becomes involved with the Assassin Brotherhood. The story follows his growth from a young man in Renaissance Italy into a skilled and influential Assassin.

Assassin's Creed II visits several Italian locations, including Florence, Monteriggioni, Venice, and Forlì. Historical figures such as Leonardo da Vinci and Niccolò Machiavelli assist or interact with Ezio, while the game uses fictional conspiracies to connect them to the wider Assassin-Templar conflict. Ezio later returns as the protagonist of Brotherhood and Revelations, making him the central figure of a trilogy. Altaïr is the protagonist of the first game, while Cesare Borgia is an important antagonist in Brotherhood rather than the hero of Assassin's Creed II.