Mariano Navone defeated Novak Djokovic in the first round of the 2026 US Open men's singles draw.
Navone won the match in five sets, overcoming Djokovic after a contest that began with a tiebreak and continued through four more sets. The result was one of the opening round's major surprises because Djokovic was the No. 4 seed.
Djokovic entered the tournament as one of the most decorated players in tennis history and a former US Open champion. A first-round defeat meant he could not add another title in New York in 2026.
The result also gave Navone a particularly notable Grand Slam victory. It was not simply a win over a seeded opponent; it was a win over a player with multiple major championships and extensive US Open experience.