The 291 gallery hosted Georgia O'Keeffe's first solo exhibition in 1917.
The exhibition took place at 291, the avant-garde New York gallery operated by photographer and art dealer Alfred Stieglitz. Stieglitz had first seen O'Keeffe's abstract charcoal drawings after they were sent to him by her friend Anita Pollitzer, and he arranged for them to be shown at his gallery.
The gallery was formally associated with Stieglitz's photography studio at 291 Fifth Avenue. It had earlier introduced American audiences to European modernism and exhibited artists including Pablo Picasso, Henri Matisse, and Paul Cézanne.
O'Keeffe's 1917 exhibition was a turning point in her career and began her long professional relationship with Stieglitz. The gallery's name is usually written simply as 291, not as a conventional surname-based gallery name.