Abiquiu became closely associated with Georgia O'Keeffe's home and studio in New Mexico. She acquired the Abiquiu property in 1945 and renovated it over several years, eventually making it one of her principal residences and workplaces.
The house contains architectural features that appeared in her art, including a distinctive door opening onto a courtyard wall. O'Keeffe repeatedly painted that doorway, transforming a familiar feature of her home into a focused subject through changes of color, light, and composition.
Abiquiu is often confused with Ghost Ranch, another New Mexico location strongly linked to O'Keeffe. Ghost Ranch was a separate retreat and source of imagery, while the Abiquiu house became her permanent home after she left New York. The Georgia O'Keeffe Home and Studio is now preserved as a historic site and offers insight into how her surroundings shaped her working methods.