Venice is a major Italian setting in Assassin’s Creed II and is famous for its canals.
Ezio Auditore reaches Venice during the game’s Renaissance storyline. The city provides a distinctive environment of waterways, bridges, palaces, markets, and narrow streets. Several important missions occur there, including events involving the Venetian Carnival and the Palazzo Ducale.
Assassin’s Creed II does not take place only in Venice. Ezio’s journey also includes Florence, Monteriggioni, San Gimignano, Forlì, and other locations across Renaissance Italy. Florence is especially important because it is Ezio’s birthplace and the location where much of his early story unfolds.
The game’s Venice is a historical recreation rather than a modern travel simulation. It depicts the city during the late fifteenth century, before the modern tourism industry and contemporary urban landscape. The canals remain a useful identifying feature, but the question specifically concerns the historical city visited by Ezio, not every location in the game.