Which Georgia O'Keeffe painting is in the collection of the Art Institute of Chicago and depicts a red landscape with a white skull?

Cow's Skull: Red, White, and Blue is the Georgia O'Keeffe painting in the Art Institute of Chicago's collection that depicts a white skull against a red, white, and blue setting.

O'Keeffe painted the work in 1931 after becoming fascinated by animal bones found in the New Mexico desert. The cow's skull is presented frontally, with the broad, simplified forms making it resemble both a natural specimen and a symbolic emblem.

The title refers to the colors in the composition, not to a literal scene of the American flag. O'Keeffe frequently used bones as structural forms and explored their contours in paintings, drawings, and photographs.

It is easy to confuse this work with Ram's Head, White Hollyhock-Hills, which also combines a skull with a flower and New Mexico scenery. The two paintings differ in animal, composition, and title.