Alfred Stieglitz operated the gallery known as 291 when he first exhibited Georgia O'Keeffe's work in 1916.
The gallery was located at 291 Fifth Avenue in New York City, and its address became its name. Stieglitz used 291 to present European avant-garde art alongside innovative American artists. In 1916, photographer and art promoter Anita Pollitzer showed Stieglitz O'Keeffe's abstract charcoal drawings, and he exhibited them at 291 without her prior permission.
The exhibition began O'Keeffe's long professional relationship with Stieglitz. He later became her husband, but 291 predates their marriage and is best identified by its number rather than by a personal name. Stieglitz closed 291 in 1917, after which he continued promoting O'Keeffe through other New York galleries.