Georgia O'Keeffe's 1931 work Cow's Skull: Red, White, and Blue depicts a cow's skull.
O'Keeffe painted the work after collecting animal bones in New Mexico, where bleached bones were common in the desert landscape. The skull is shown vertically against a broad field of red, white, and blue, giving the composition a strong American visual identity.
The painting combines a natural object with colors associated with the United States. O'Keeffe often isolated bones and skulls rather than treating them as incidental details in a landscape. Their weathered shapes became subjects in their own right.
The animal is specifically a cow, not a buffalo or horse. O'Keeffe made several paintings and drawings of bones, so the titles and species can be confused when her New Mexico works are discussed together.