What is the name of Plankton's computer wife?

Plankton's computer wife is Karen.

Karen is an artificially intelligent supercomputer who serves as Plankton's partner, adviser, and frequent voice of reason. Together, they run the Chum Bucket, the unsuccessful restaurant located across from the Krusty Krab. Karen is usually more capable than Plankton at designing schemes to steal the Krabby Patty formula.

Karen first appeared with Plankton in the episode “Plankton!”, which introduced her as his computer assistant. The series later established that she and Plankton are married; in one running joke, “WIFE” is explained as an acronym for “Wired Integrated Female Electroencephalograph.” Her name was inspired by Karen Hillenburg, creator Stephen Hillenburg’s wife.

A common mix-up is confusing Karen with real-world voice assistants such as Siri, Alexa, or Cortana. Those are wrong for this fictional character: Karen is a SpongeBob character, voiced by Jill Talley, and is specifically Plankton’s waterproof supercomputer wife.