What hospital serves as the main setting in House M.D.?

Princeton-Plainsboro Teaching Hospital is the main hospital setting in House M.D.

The fictional New Jersey teaching hospital is where Gregory House leads the Department of Diagnostic Medicine. Most episodes follow House and his team as they investigate patients whose symptoms resist ordinary explanations, while other storylines involve hospital administration and relationships among the staff.

Princeton-Plainsboro is fictional, but the series used real locations for some exterior images. Princeton University’s Frist Campus Center was used as the exterior of the hospital in the early seasons, creating a recognizable visual identity for the show.

Viewers sometimes confuse the hospital with Princeton University itself or with real hospitals named Princeton-Plainsboro. In the story, it is a teaching hospital with multiple departments and a large medical staff. Its name also reflects the setting’s connection to the fictionalized Princeton area of New Jersey.