The 2015 video game about knights defending humanity from wolf-like humanoids is The Order: 1886. It is a third-person action-adventure game developed by Ready at Dawn and published by Sony Computer Entertainment for the PlayStation 4.
The story takes place in an alternate-history version of Victorian London. The Order is descended from King Arthur’s Knights of the Round Table, and its members use Arthurian names such as Galahad, Percival and Igraine. They battle “Half-Breeds,” supernatural human-animal creatures that include the werewolf-like Lycans described in the question.
The game combines historical figures and steampunk technology with its fictional mythology. Nikola Tesla appears as an inventor who supplies the knights with advanced weapons and equipment, while the plot also involves political unrest, industrial power and secret organizations.
The title’s “1886” refers to the game’s setting rather than its release year; the game launched on February 20, 2015. It is a single-player PlayStation 4 title and is known for its cinematic presentation, alternate-history London and heavily scripted storytelling.