"Isolate and Medicate" is the sixth studio album by the South African rock band Seether. The album was released on July 1, 2014, through Bicycle Music, Concord Music Group, and Spinefarm Records.
Seether recorded the album during 2013 and 2014, with Brendan O'Brien serving as producer for most of the tracks. It followed "Holding Onto Strings Better Left to Fray" and preceded "Poison the Parish." The record continued the band's blend of post-grunge, hard rock, alternative rock, and alternative metal.
The album produced several singles, including "Words as Weapons," "Same Damn Life," "Nobody Praying for Me," and "Save Today." It was also notable as Seether's first album to receive a vinyl LP release. A common mix-up is counting compilations, reissues, or live releases when determining the band's studio-album sequence; in the standard studio discography, "Isolate and Medicate" is number six.