Georgia O'Keeffe painted Cow's Skull: Red, White, and Blue in 1931.
The painting presents a weathered cow skull centered against a vertically divided field of red, white, and blue. Its title directly identifies both the object and the colors, giving the work a distinctly American visual identity.
O'Keeffe encountered animal bones in the New Mexico landscape and repeatedly incorporated them into her art. She was interested in their shapes, surfaces, and ability to suggest endurance rather than treating them merely as symbols of death.
This painting is often discussed alongside O'Keeffe's New Mexico works, although it should not be confused with her flower paintings or with other skull compositions. The date places it in the early 1930s, after her first New Mexico visit in 1929.