In Assassin's Creed Revelations, Constantinople is the main setting for Ezio's later journey.
Ezio travels to Constantinople, the capital of the Byzantine Empire, while searching for keys connected to Altaïr Ibn-La'Ahad's legacy. The city is divided into districts and includes communities shaped by Byzantine, Ottoman, and other cultural influences. Ezio also meets Yusuf Tazim, leader of the local Assassin faction, who helps him navigate the city.
Jerusalem and Damascus are strongly connected with the first Assassin's Creed game, while Alexandria is a major setting in Assassin's Creed Origins. Revelations instead focuses on Constantinople and Cappadocia, and it brings together Ezio's story with Altaïr's through the Masyaf keys and memory sequences. The historical city was known as Constantinople during the game's period; it was later commonly called Istanbul.