Mewtwo’s DNA was derived from Mew in the Pokémon franchise’s original story.
Mewtwo is presented as an artificial Pokémon created through scientific experimentation. Researchers used genetic material from Mew and altered it through gene-splicing experiments, producing a creature with immense psychic power.
The relationship between the two Pokémon is central to the story of Pokémon: The First Movie. Mew represents a rare, naturally occurring Pokémon, while Mewtwo is a laboratory creation who questions whether being engineered makes it less authentic or less deserving of existence.
Mew and Mewtwo are separate species with different Pokédex numbers and roles. Mew is National Pokédex number 151, while Mewtwo is number 150. The numbering places Mewtwo immediately before Mew, reflecting their narrative connection even though Mewtwo is not a direct evolutionary form of Mew.