Fleming's 1917 antiseptics article appeared in which medical journal?

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Fleming’s 1917 article on antiseptics appeared in The Lancet.

The paper was titled “The Physiological and Antiseptic Action of Flavine,” with observations on how antiseptics should be tested. Fleming wrote it while serving with the Royal Army Medical Corps during the First World War, when he was studying infected wounds in military hospitals in France.

His experiments challenged the assumption that stronger antiseptic treatment was always better. He found that antiseptics could damage leucocytes—white blood cells that help defend tissue—without reaching bacteria deep inside irregular wounds. In some cases, treatment could therefore impair the body’s own protection while leaving infection sheltered.

The article is not a penicillin paper: Fleming’s famous work on the mould-derived antibacterial substance was published later, in 1929, in the British Journal of Experimental Pathology. The 1917 Lancet study instead established an important part of his earlier research career.

Source: Wikipedia · fact-checked Sept. 2026

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