Which team did Messi score five goals against in a Champions League match?

Messi scored five goals against Bayer Leverkusen in Barcelona’s 7–1 Champions League victory on 7 March 2012. It was the second leg of the 2011–12 round-of-16 tie at Camp Nou.

Messi scored twice in the first half, then added three more after the interval. His performance made him the first player to score five goals in a single UEFA Champions League match. Barcelona advanced 10–2 on aggregate after also winning the first leg 3–1 in Germany.

The result is often confused with Messi’s other extraordinary Champions League performances. He scored four against Arsenal in 2010, while Luiz Adriano later matched the five-goal feat for Shakhtar Donetsk against BATE Borisov in 2014. Bayer Leverkusen is therefore the canonical answer to this question, not Arsenal, Bayern Munich or Shakhtar Donetsk.