Which space shuttle had the first female pilot, Eileen Collins?

The space shuttle Discovery had the first female pilot, Eileen Collins.

Collins served as pilot of STS-63, Discovery’s twentieth mission, which launched on February 3, 1995. The flight was the second Shuttle-Mir mission and included a close approach to Russia’s Mir space station, helping test procedures for later docking missions.

Discovery’s crew also included mission specialist Bernard Harris, who became the first African-American to walk in space. The shuttle completed a 20-foot approach to Mir, but it did not dock because the mission was primarily a rendezvous and systems test.

Collins later became the first woman to command a space shuttle, leading STS-93 aboard Columbia in 1999. That later achievement is sometimes confused with her earlier milestone as a pilot. For this question, the canonical answer is Discovery, the orbiter used for her first spaceflight and historic pilot assignment.