Which Sherlock Holmes address is also Dr. Gregory House’s apartment address in House M.D.?

Dr. Gregory House’s apartment address in House M.D. is 221B Baker Street.

The address is a deliberate reference to Sherlock Holmes, whose fictional London home is 221B Baker Street. House M.D. frequently draws parallels between House and Holmes: both are exceptional problem-solvers, use observation and deduction, and maintain a close relationship with a trusted friend modeled partly on Dr. John Watson.

In the television series, House’s apartment is in New Jersey, so the address is an allusion rather than a literal London location. The reference helps signal the show's mystery structure, in which unexplained symptoms function like clues in a detective case.

The connection is reinforced by other details, including House’s surname, which echoes Holmes, and Wilson’s role as a loyal but often exasperated companion. The address is therefore a recognizable literary homage, not merely a random apartment number.