Mewtwo is the main genetic creation featured as the antagonist in Pokémon: The First Movie.
The film, released in Japan in 1998 and internationally in 1999, follows Mewtwo after scientists create it from genetic material linked to the Mythical Pokémon Mew. Mewtwo questions its origins and seeks to prove that artificially created Pokémon can surpass naturally born ones.
The story’s central conflict brings Ash, Pikachu, and other Trainers to Mewtwo’s island. Mewtwo invites them under false pretenses and stages battles between cloned Pokémon and their originals. The film explores identity, creation, and whether origins determine a being’s worth.
Mew and Mewtwo are often confused because they share a Pokédex family connection and similar names. Mew is the ancient Mythical Pokémon associated with the genetic template, while Mewtwo is the engineered clone and the movie’s principal opposing figure.