Which Lexus model was the first mass-production rear-wheel-drive luxury hybrid car?

The Lexus GS 450h was the first mass-production rear-wheel-drive luxury hybrid car.

Lexus unveiled the GS 450h at the 2005 New York International Auto Show, and the hybrid joined the GS range in 2006 for the 2007 model year. It combined a 3.5-liter V6 gasoline engine with electric motors and Lexus Hybrid Drive, sending power through a planetary continuously variable transmission.

Unlike the front-wheel-drive Toyota Prius and Lexus RX 400h, the GS 450h was engineered as a performance-oriented rear-wheel-drive luxury sedan. Its hybrid system delivered strong acceleration while also reducing emissions; the model received a Super Ultra Low Emissions Vehicle rating in the United States.

The Lexus LS 600h arrived later as a larger flagship hybrid, while the CT 200h was a smaller front-wheel-drive hatchback introduced in 2010. Those models are therefore easy distractors, but neither fits the question’s combination of mass production, luxury positioning, hybrid power, and rear-wheel drive.