Which House, M.D. episode is set largely in an airplane during a flight?

The House, M.D. episode set largely in an airplane during a flight is “Airborne.”

“Airborne” is the fourteenth episode of the third season. House and Cuddy are traveling by airplane when several passengers become ill, creating a medical crisis in a confined environment without the full resources of Princeton-Plainsboro.

The episode uses the flight setting to change the usual diagnostic format. Instead of examining one patient in a hospital, House must assess multiple sick travelers while dealing with limited equipment, uncertain exposure histories, and the possibility of a contagious illness. The unusual setting also creates comic and procedural tension between House and Cuddy.

“Airborne” aired in 2007 and is often remembered alongside other location-focused episodes, especially “Locked In,” in which the patient’s perspective shapes the storytelling. Those episodes are distinct: “Airborne” centers on an in-flight outbreak, while “Locked In” takes place primarily in a hospital setting.