Which House, M.D. episode features Amber Volakis’s death?

“Wilson’s Heart” is the House, M.D. episode that features Amber Volakis’s death. It is the twenty-second and final episode of the show’s fourth season, broadcast in the United States on May 19, 2008.

The episode follows the consequences of a bus accident involving House and Amber. As the doctors reconstruct what happened, they discover that Amber has taken amantadine, a drug that becomes dangerous because of her kidney failure. Her condition cannot be reversed, and she dies with Wilson beside her.

“Wilson’s Heart” follows “House’s Head,” the season’s preceding episode, which begins the mystery surrounding the accident. Amber, played by Anne Dudek, had been a recurring competitor for a place on House’s team and later became Wilson’s partner. The title emphasizes the event’s effect on Wilson rather than only the medical diagnosis.