Which House M.D. character dies in the season-four finale after a bus accident?

Amber Volakis dies in the House M.D. season-four finale after injuries from a bus accident. The two-part finale, “House’s Head” and “Wilson’s Heart,” reveals the circumstances surrounding her death.

Amber, played by Anne Dudek, was one of the applicants competing for a place on House’s diagnostic team during season four. House nicknamed her “Cutthroat Bitch” because of her aggressive ambition and willingness to compete. She later became Wilson’s girlfriend, making her death especially devastating for him.

After a night involving House and Amber, their bus crashes. Amber has taken amantadine, a drug that cannot be cleared properly because the accident has damaged her kidneys. House’s fragmented memories gradually reveal what happened, and the diagnosis is confirmed too late to save her.

Amber is not Remy Hadley, commonly called Thirteen, who becomes another major member of House’s team. The accident storyline and its consequences significantly change House and Wilson’s relationship in the following season.