Which Grey's Anatomy episode is listed as the series' most-watched episode?

The story behind the answer

“It’s the End of the World” is listed as Grey’s Anatomy’s most-watched episode.

The episode is the 16th installment of season 2 and the 25th episode overall. It originally aired on February 5, 2006, immediately after Super Bowl XL on ABC. That unusually large lead-in helped it reach roughly 37.88 million viewers, with some contemporary episode references rounding the figure to 38.1 million.

Its record-setting audience is closely tied to the episode’s high-stakes plot. A patient arrives with unexploded ammunition lodged in his chest, forcing the hospital into a Code Black while Meredith, Cristina, Derek, and others struggle to keep the patient alive. Christina Ricci guest-stars as paramedic Hannah Davies, and Kyle Chandler plays bomb-disposal leader Dylan Young.

A common mix-up is “As We Know It,” the following episode in the two-part bomb storyline. Although both episodes are often discussed together and both were well received, “It’s the End of the World” is the installment credited with the series’ highest viewership.

Source: Wikipedia · fact-checked Sept. 2026

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