Which fictional address links Gregory House to Sherlock Holmes in House M.D.?

House M.D. links Gregory House to Sherlock Holmes through the fictional address 221B Baker Street.

In the series, House’s apartment number is 221B. The address is a direct reference to Sherlock Holmes’s famous London residence in Arthur Conan Doyle’s detective stories. The connection is part of a broader design: House and Holmes both rely on deduction, have difficult personalities, and are aided by loyal friends modeled in part on Dr. Watson.

James Wilson occupies the Watson-like role in House’s life, while House’s surname itself resembles Holmes’s. The medical cases function like mysteries, with symptoms serving as clues and the final diagnosis acting as the solution.

The address is sometimes mistaken for a real New Jersey location or for Holmes’s complete canonical street address. In both fictional worlds, 221B Baker Street is primarily a literary reference used to signal the relationship between the two characters.