Which fictional address does House share with Sherlock Holmes in House M.D.?

House’s fictional address in House M.D. is 221B Baker Street.

The address is a deliberate reference to Sherlock Holmes, whose famous London residence is 221B Baker Street. Gregory House is modeled partly on Holmes, especially in his use of deduction, his distrust of ordinary explanations, and his reliance on a close friend who challenges him.

The television series relocates the address to New Jersey rather than London. House’s apartment is identified as 221B Baker Street, Princeton, New Jersey, reinforcing the literary parallel without making the character a direct adaptation of Holmes.

Other Holmes-inspired details include the names James Wilson and Irene Adler-related references, as well as House’s diagnostic investigations functioning like detective cases. The address is therefore more than a setting detail: it signals the show’s central creative influence.